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Chemical Safety

The NIH chemical safety program provides guidance, policies, and resources to help laboratories and other work areas manage chemical hazards safely. The program promotes safe work practices and ensures compliance with OSHA's Laboratory Standard (29 CFR 1910.1450), Hazard Communication Standard (29 CFR 1910.1200), and applicable NIH policies.

Select​ a topic below to access guidance documents, requirements, and resources, or to learn more about that topic.​


Safety Topics
📄 Safety Policies

Access the Chemical Hygiene Plan, Hazard Communication Plan, and other required policies and guidance documents for safely managing chemical hazards. 

📋 Report an Incident

Report all chemical incidents and near misses promptly to the Division of Safety. 

📦 Chemical Inventory

An accurate chemical inventory is essential for managing chemicals safely and preventing laboratory incidents. The LabArchives Chemical Inventory module is a helpful tool to create and maintain your inventory. 

🧪 Particularly Hazardous Substances (PHS)

PHS are carcinogens, reproductive toxins, and highly toxic chemicals that require special handling, storage, and disposal. 



🚨 Spills and Emergencies

Know how to respond to chemical spills and emergencies before starting to work with chemicals.​                 

🗄️ Chemical Storage

Store chemicals safely by segregating incompatible materials to prevent fires, reactions, and other incidents. Review the fact sheets and reference materials for guidance on safe chemical storage.                   

🧫 Peroxide Formers

Peroxide-forming chemicals can react with oxygen in the air over time to form unstable and potentially explosive peroxides. Proper labeling, periodic testing, and timely disposal can help prevent incidents.​​                   

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💨 Chemical Fume Hood

A chemical fume hood is the primary engineering control for reducing exposure to hazardous chemicals — learn how to use it safely.             

🔥 Flammable Chemicals and Emergencies

Improper storage of flammable materials can create hazardous conditions. Limit quantities stored and use approved flammable storage cabinets to reduce the risks.              

⚗️ Pyrophoric & Water-Reactive Chemicals

Pyrophoric and water-reactive chemicals can ignite or react violently when exposed to air or moisture. Follow established guidelines when working with these chemicals to prevent serious incidents.              


Associated Programs
📊 Chemical Monitoring

OSHA requires exposure monitoring for certain hazardous chemicals to assess personal exposures and ensure appropriate controls are in place. Refer to the NIH Chemical Monitoring program for details.             

🛢️ Compressed Gases & Cryogens

​Compressed gases and cryogens present unique hazards due to pressure, extreme temperatures, and potential for exposure to hazardous chemicals. NIH has established a safety program to manage these hazards and promote safe handling, storage, and use across​ the organization.             

Need help right now?
Choose the pathway that matches your situation.

​​​🚨 Emergency now

Fire, serious exposure, or an uncontrolled / high-hazard spill.


Chemical Waste Services (Bethesda):
(301) 496-4710
Spill or exposure guidance

When the situation can be safely assessed.

View guidance →
Report an incident

Reporting and follow-up once stable.

Report now →​