Chuan Wu (NIH/NCI)
The cover image illustrates that sialylated mucin proteins (saguaros with thorns) harbor symbiotic commensal bacteria (gilded flickers), protecting the intestinal tissue from pathogens (snakes and hawks). Loss of sialylation (saguaros without thorns) results in pathogenic bacteria invasion (snakes).
Mucus sialylation determines intestinal hostcommensal homeostasis
Cell 2022 Mar 31;185(7)
Illustrator: Alan Hoofring