Because of a lapse in government funding, the information on this website may not be up to date, transactions submitted via the website may not be processed, and the agency may not be able to respond to inquiries until appropriations are enacted. The NIH Clinical Center (the research hospital of NIH) is open. For more details about its operating status, please visit cc.nih.gov. Updates regarding government operating status and resumption of normal operations can be found at opm.gov.

Lattice Formation of Clathrin

Client:
Justin Taraska (NIH/NHLBI) et al.,
Project Description:
Dozens of proteins capture, polymerize and reshape the clathrin lattice during clathrin-mediated endocytosis (CME). Six key observed structural phenomena of clathrin-associated proteins are hypothesized to be occurring during different stages of pit development. The illustration supports the finding that endocytic proteins distribute into distinct spatial zones in relation to the edge of the clathrin lattice.
Manuscript title:
Endocytic proteins are partitioned at the edge of the clathrin lattice in mammalian cells.
Nat Cell Biol. 2017 April;19(4):352-361
PMID: 28346440
PubMed
Illustrator: Ethan Tyler