Image created by Ethan Tyler of NIH Medical Arts supports a research article describing the use of large-scale genomics and transcriptomics to identify promising drugs for disease such as amyotrophic lateral sclerosis (ALS) and frontotemporal dementia. The illustration depicts a selected drug (yellow pill), symbolizing successful repurposing of a therapeutic candidate. In contrast, other drugs are depicted as being rejected or left behind, representing those deemed ineffective by the screening process. This illustrates a rigorous, data-driven approach used to narrow down effective treatments from a broad pool of candidates. Artwork was created with Autodesk 3ds Max and Adobe Illustrator.