Because of a lapse in government funding, the information on this website may not be up to date, transactions submitted via the website may not be processed, and the agency may not be able to respond to inquiries until appropriations are enacted. The NIH Clinical Center (the research hospital of NIH) is open. For more details about its operating status, please visit cc.nih.gov. Updates regarding government operating status and resumption of normal operations can be found at opm.gov.

Arginine Promotes T Cell Memory

Client:
Rigel Kishton (NIH/NCI)
Project description:
Increased levels of arginine in T cells result in the inhibition of glucose uptake and the promotion of mitochondrial oxidative metabolism. Concurrently, arginine modulates the conformation of several proteins involved in chromatin regulation. Together, these alterations in cell metabolism and perhaps gene expression driven by arginine promote the acquisition of a memory phenotype in T cells. This phenotype results in increased T cell survival, persistence, and an improved antitumor response.
Manuscript title:
Arginine Arms T Cells to Thrive and Survive.
Cell Metab. 2016 Nov 8;24(5):647-648.
PMID: 27829132
PubMed
Illustrator: Erina He